Jak1^tm1Kuw
Targeted Allele Detail

Summary

• Symbol: Jak1^tm1Kuw
• Name: Janus kinase 1; targeted mutation 1, Kay-Uwe Wagner
• MGI ID: MGI:5688302
• Synonyms: Jak1fl
• Gene: Jak1 Location: Chr4:101009564-101122479 bp, - strand Genetic Position: Chr4, 46.19 cM
• Alliance: Jak1^tm1Kuw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235355
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The second coding exon was flanked by loxP sites. A frt-flanked PGK-neo cassette was inserted in the intron following the floxed exon. (J:235355)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Jak1 Mutation: 50 strains or lines available

References

• Original: J:235355 Sakamoto K, et al., Generation of Janus kinase 1 (JAK1) conditional knockout mice. Genesis. 2016 Nov;54(11):582-588
• All: 5 reference(s)