Jak1^tm1.1Kuw
Targeted Allele Detail

Summary

• Symbol: Jak1^tm1.1Kuw
• Name: Janus kinase 1; targeted mutation 1.1, Kay-Uwe Wagner
• MGI ID: MGI:5688350
• Gene: Jak1 Location: Chr4:101009564-101122479 bp, - strand Genetic Position: Chr4, 46.19 cM
• Alliance: Jak1^tm1.1Kuw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235355
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele is a derivative of Jak1^tm1Kuw in which the loxP-flanked exon 2 was deleted in the germline by Cre-mediated recombination, leaving the frt-flanked PGK-neo in the intron following the floxed region. (J:235355)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak1 Mutation: 50 strains or lines available

References

• Original: J:235355 Sakamoto K, et al., Generation of Janus kinase 1 (JAK1) conditional knockout mice. Genesis. 2016 Nov;54(11):582-588
• All: 2 reference(s)