Ksr2^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ksr2^m1Btlr
• Name: kinase suppressor of ras 2; mutation 1, Bruce Beutler
• MGI ID: MGI:5688498
• Synonyms: gigante
• Gene: Ksr2 Location: Chr5:117552067-117906061 bp, + strand Genetic Position: Chr5, 56.88 cM
• Alliance: Ksr2^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion at base pair 117,671,449 (v38) on chromosome 5, or base pair 257,680 in the GenBank genomic region NC_000071. The mutation corresponds to residue 2,103 in the mRNA sequence NM_001114545 within exon 7 of 21 total exons. The mutation results in a cysteine (C) to serine (S) substitution at position 426 (C426S). (J:224661)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ksr2 Mutation: 42 strains or lines available

References

• Original: J:224661 SoRelle J, et al., Mutagenetix entry for gigante. MGI Direct Data Submission. 2015
• All: 1 reference(s)