Gt(ROSA)26Sor^{tm2(Stat3*Y705F)Mci}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(Stat3*Y705F)Mci}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Roderick R McInnes
• MGI ID: MGI:5688570
• Synonyms: R26^{LSL-Stat3Y705F}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(Stat3*Y705F)Mci} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216928
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(Stat3*Y705F)Mci} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Stat3 (MGI:103038)

• Mutation details: A splice acceptor site, floxed pgk-neo-stop cassette, and mouse Stat3 cDNA with a Y705F mutation were inserted in intron 1 via homologous recombination. (J:216928)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1040 strains or lines available

References

• Original: J:216928 Jiang K, et al., STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5716-23
• All: 1 reference(s)