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Tlr4Lps-6Btlr
Chemically induced Allele Detail
Summary
Symbol: Tlr4Lps-6Btlr
Name: toll-like receptor 4; defective lipopolysaccharide response 6 Bruce Beutler
MGI ID: MGI:5688584
Synonyms: milquetoast
Gene: Tlr4  Location: Chr4:66745788-66765338 bp, + strand  Genetic Position: Chr4, 34.66 cM
Alliance: Tlr4Lps-6Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced an A to T transversion at base pair 66,839,444 (v38) on chromosome 4, or base pair 11,634 in the GenBank genomic region NC_000070. The mutation corresponds to residue 754 in the mRNA sequence NM_021297 within exon 3 of 3 total exons. The mutation results in a histidine (H) to leucine (L) substitution at position 158 (H158L) in the protein. (J:224667)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:  91 strains or lines available
References
Original:  J:224667 Wang Y, et al., Mutagenetix entry for milquetoast. MGI Direct Data Submission. 2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory