Tlr4^Lps-6Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr4^Lps-6Btlr
• Name: toll-like receptor 4; defective lipopolysaccharide response 6 Bruce Beutler
• MGI ID: MGI:5688584
• Synonyms: milquetoast
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^Lps-6Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to T transversion at base pair 66,839,444 (v38) on chromosome 4, or base pair 11,634 in the GenBank genomic region NC_000070. The mutation corresponds to residue 754 in the mRNA sequence NM_021297 within exon 3 of 3 total exons. The mutation results in a histidine (H) to leucine (L) substitution at position 158 (H158L) in the protein. (J:224667)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 91 strains or lines available

References

• Original: J:224667 Wang Y, et al., Mutagenetix entry for milquetoast. MGI Direct Data Submission. 2015
• All: 1 reference(s)