Map3k8^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Map3k8^m3Btlr
• Name: mitogen-activated protein kinase kinase kinase 8; mutation 3, Bruce Beutler
• MGI ID: MGI:5688599
• Synonyms: gnostic_gospel
• Gene: Map3k8 Location: Chr18:4331325-4352978 bp, - strand Genetic Position: Chr18, 2.73 cM
• Alliance: Map3k8^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to T transition at base pair 4,333,965 (v38) on chromosome 18, or base pair 19,517 in the NC_000084 GenBank genomic region. The mutation corresponds to residue 1,250 in the mRNA sequence NM_008713 within exon 7 of 8 total exons. The mutation results in an arginine (R) to cysteine (C) substitution at position 376 (R376C) in the protein. (J:224668)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k8 Mutation: 41 strains or lines available

References

• Original: J:224668 Sun L, et al., Mutagenetix entry for gnostic_gospel. MGI Direct Data Submission. 2015
• All: 1 reference(s)