Tlr3^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr3^M1Btlr
• Name: toll-like receptor 3; mutation 1, Bruce Beutler
• MGI ID: MGI:5688601
• Synonyms: Rakshasa
• Gene: Tlr3 Location: Chr8:45848702-45864112 bp, - strand Genetic Position: Chr8, 25.31 cM, cytoband B2
• Alliance: Tlr3^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C transversion at base pair 45,397,697 (v38) on chromosome 8, or base pair 14,253 in the GenBank genomic region NC_000074. The mutation corresponds to residue 2,523 in the mRNA sequence NM_126166 within exon 6 of 7 total exons. The mutation results in a valine (V) to alanine (A) substitution at position 721 (V271A) in the protein. (J:224670)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr3 Mutation: 68 strains or lines available

References

• Original: J:224670 Sun L, et al., Mutagenetix entry for Rakshasa. MGI Direct Data Submission. 2015
• All: 1 reference(s)