Enho^tm1Cmwo
Targeted Allele Detail

Summary

• Symbol: Enho^tm1Cmwo
• Name: energy homeostasis associated; targeted mutation 1, Chi-Ming Wong
• MGI ID: MGI:5688642
• Synonyms: adrKO
• Gene: Enho Location: Chr4:41638144-41640302 bp, - strand Genetic Position: Chr4, 21.8 cM, cytoband B1
• Alliance: Enho^tm1Cmwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216870
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted in the 5' region of exon 2 and 126 bp including a loxP site was inserted in the 3' region via homologous recombination. RT-PCR detected no change in mRNA expression of Enho or Dnaic1. Western blot analysis confirmed the absence of ENHO protein expression. (J:216870)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Enho Mutation: 8 strains or lines available

References

• Original: J:216870 Wong CM, et al., Adropin is a brain membrane-bound protein regulating physical activity via the NB-3/Notch signaling pathway in mice. J Biol Chem. 2014 Sep 12;289(37):25976-86
• All: 1 reference(s)