Slc12a6^tm2.1Dlp
Targeted Allele Detail

Summary

• Symbol: Slc12a6^tm2.1Dlp
• Name: solute carrier family 12, member 6; targeted mutation 2.1, Eric Delpire
• MGI ID: MGI:5688752
• Synonyms: KCC3^flox
• Gene: Slc12a6 Location: Chr2:112096659-112193508 bp, + strand Genetic Position: Chr2, 56.99 cM
• Alliance: Slc12a6^tm2.1Dlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217087
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 6 and an FRT and loxP flanked pgk-neo cassette was inserted in intron 7 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 7 floxed. (J:217087)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a6 Mutation: 120 strains or lines available

References

• Original: J:217087 Ding J, et al., Deletion of KCC3 in parvalbumin neurons leads to locomotor deficit in a conditional mouse model of peripheral neuropathy associated with agenesis of the corpus callosum. Behav Brain Res. 2014 Nov 1;274:128-36
• All: 1 reference(s)