Myf6^{tm1.1(cre/Esr1*)Cklr}
Targeted Allele Detail

Summary

• Symbol: Myf6^{tm1.1(cre/Esr1*)Cklr}
• Name: myogenic factor 6; targeted mutation 1.1, Charles Keller
• MGI ID: MGI:5688769
• Synonyms: Myf6CreER
• Gene: Myf6 Location: Chr10:107328709-107330584 bp, - strand Genetic Position: Chr10, 55.96 cM
• Alliance: Myf6^{tm1.1(cre/Esr1*)Cklr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214957
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Myf6^{tm1.1(cre/Esr1*)Cklr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myf6 (MGI:97253)

• Mutation details: Homologous recombination in ES cells inserted an IRES-creER^TM-FRT-Neo-FRT sequence into the 3' UTR following the stop codon in exon 3. Flp-mediated recombination removed the selection cassette. (J:214957)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myf6 (mouse) Summary of all recombinase alleles driven by Myf6. Comparative matrix view of recombinase activities Alliance mouse Myf6 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myf6 Mutation: 19 strains or lines available

References

• Original: J:214957 Abraham J, et al., Lineage of origin in rhabdomyosarcoma informs pharmacological response. Genes Dev. 2014 Jul 15;28(14):1578-91
• All: 1 reference(s)