Fzd10^tm1.1Nat
Targeted Allele Detail

Summary

• Symbol: Fzd10^tm1.1Nat
• Name: frizzled class receptor 10; targeted mutation 1.1, Jeremy Nathans
• MGI ID: MGI:5688883
• Synonyms: Fzd10-CKO-AP
• Gene: Fzd10 Location: Chr5:128678170-128681157 bp, + strand Genetic Position: Chr5, 67.67 cM
• Alliance: Fzd10^tm1.1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted within the first coding exon 5' of the initiator methionine codon, and 3' of an SV40 polyadenylation signal that was inserted immediately 3' of the 3' UTR. The following DNA segments were added immediately downstream of the 3' loxP site: (1) the coding region for human placental alkaline phosphatase (AP), and (2) a phosphoglycerate kinase (PGK)-Neo cassette flanked by FRT sites (FNF). Flp-mediated recombination removed the FRT-flanked neo cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fzd10 Mutation: 25 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)