About   Help   FAQ
Del(16Setd4-Kcnj6)12Yey
Targeted Allele Detail
Summary
Symbol: Del(16Setd4-Kcnj6)12Yey
Name: deletion, Chr 16, Y Eugene Yu 14; deletion, Chr 16, Y Eugene Yu 12
MGI ID: MGI:5689383
Synonyms: Df(16)5, Df(16)5Yey
Gene: Del(16Setd4-Kcnj6)12Yey  Location: unknown  Genetic Position: Chr16, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:224899
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(16Setd4-Kcnj6)12Yey involves 15 genes/genome features (Setd4, Cbr1, Cbr3 ...) View all
 
Mutation detailsChromosome-engineering cassettes were inserted into mouse Chromosome 16 to bracket a span between the SET domain containing 4 (Setd4) gene and the potassium inwardly-rectifying channel, subfamily J, member 6 (Kcnj6) gene. The cassette placed at the proximal locus (MICER clone MHPN267e05) was targeted upstream of Setd4 and contained a neomycin resistance gene, a loxP site, a 5' portion of an HPRT minigene, and a tyrosinase minigene. The cassette placed at the distal locus (MICER clone MHPP54c08) was targeted downstream of the Kcnj6 gene and contained an agouti transgene, a 3' portion of an HPRT minigene, a loxP site and puromycin resistance gene. Double-targeted ES cells were transiently transfected with the cre recombinase expression vector pOG231 to remove the region from Set4 to Kcnj6, which encompasses 15 genes. FISH analysis of ES cell clones confirmed the deletions. (J:224899)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(16Setd4-Kcnj6)12Yey Mutation:  1 strain or line available
References
Original:  J:224899 Jiang X, et al., Genetic dissection of the Down syndrome critical region. Hum Mol Genet. 2015 Nov 15;24(22):6540-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory