Tpnr2^AKR/J
QTL Variant Detail

Summary

• QTL variant: Tpnr2^AKR/J
• Name: thermal pain response 2; AKR/J
• MGI ID: MGI:5689416
• QTL: Tpnr2 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: AKR/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:101430

Paw withdrawal in response to heat was studied in various inbred strains. Nociceptors (pain receptors) in C57BL/6J mice exhibited 4 times greater responses to radiant heat then did AKR/J mice. This difference facilitated the QTL mapping of the paw withdrawal response. Fifty male and 43 female ( AKR/J X C57BL/6J)F2 mice were informative in mapping Tpnr2 to mouse Chromosome 7. A second cross using 63 males and 45 female (BALB/cJ X C57BL/6J)F2 mice was also used to show a mapping of Tpnr2 to 50 cM with LODs of 6.3 in the AKR/J cross and 4.5 in the BALB/cJ cross.

10.8.2015 Curator Note: When previoulsy identified QTL are cited as confirmed or verified within the same study, using a different cross then that initially used, we have created a new QTL. We consider each distinct cross to be a separate mapping experiment. We have named the QTL identified here using the (BALB/cJ X C57BL/6J)F2 cross as Tpnr7.

References

• Original: J:101430 Mogil JS, et al., Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12938-43
• All: 1 reference(s)