Lbn10^SM/J
QTL Variant Detail

Summary

• QTL variant: Lbn10^SM/J
• Name: long bones 10; SM/J
• MGI ID: MGI:5689476
• QTL: Lbn10 Location: unknown Genetic Position: Chr17, cM position of peak correlated region/allele: 17.98 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:109795

Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.

On mouse Chromosome 17, linkage to spleen weight was detected at 13 cM near D17Mit46 (LPR=2.79). This locus is named Org9 (organ weight 9). The confidence interval spans 0 cM - 10 cM.

Lbn10 (long bones 10) mapped to 23 cM near D17Mit16 (LPR=3.80). This locus is associated with femur, humerus, and ulna lengths. Lbn10 is also associated with tibia length in female animals. Potential candidate genes mapping near Lbn10 include Wdr4, Brd2 (18.5 cM), Notch3 (20 cM), Ddr1 (21.5 cM), Rab11b (18.3 cM), Scoc (*note: this gene maps to chromosome 8 according to MGD data), Notch4 (18.7 cM), Apom, and Foxp4.

Linkage to heart weight in males was detected near D17Mit16 (LPR=2.4). This locus is namedOrg10 (organ weight 10). The Org10 confidence interval spans 32 cM - 44 cM.

References

• Original: J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• All: 1 reference(s)