Lbn6^SM/J
QTL Variant Detail

Summary

• QTL variant: Lbn6^SM/J
• Name: long bones 6; SM/J
• MGI ID: MGI:5689546
• QTL: Lbn6 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 1.91 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:109795

Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.

On mouse Chromosome 7, linkage to tibia length, Lbn6 (long bones 6), mapped to 28 cM near D7Mit21 (LPR=7.39). The Lbn6 confidence interval spans 14 cM - 54 cM. Potential candidate genes mapping near Lbn6 include Fgf21, Zscan2 (formerly Zfp29), Zfp536, Fut1 (23.2 cM), Fut2 (23.2 cM), Nr2f1 (*note: this gene maps to chromosome 13 according to MGD data), Stard5 (41.2 cM), St8sia2 (formerly Siat8b), and Kif7.

Bod4 (bone length and organs 4), mapped to 43 cM near D7Nds1 (LPR=23.17). This locus is associated with necropsy body weight, liver weight, and femur and ulna length. The confidence interval spans 44 cM - 54 cM. Previously identified QTL Adip3 (46.6 cM) may be identical to Bod4. Potential candidate genes for Bod4 include Zscan, Zfp592, Fzd4, Stard5, and Kif7.

Heart weight and kidney weight, Org5 (organ weight 5), mapped to 46 cM near D7Mit148 (LPR=20.92). The Org5 interval spans 50 cM - 56 cM.

References

• Original: J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• All: 1 reference(s)