Meis1^{tm3.1(cre/ERT2)Mtor}
Targeted Allele Detail

Summary

• Symbol: Meis1^{tm3.1(cre/ERT2)Mtor}
• Name: Meis homeobox 1; targeted mutation 3.1, Miguel Torres
• MGI ID: MGI:5689568
• Synonyms: Meis1^CreERT2
• Gene: Meis1 Location: Chr11:18830428-18968992 bp, - strand Genetic Position: Chr11, 11.11 cM
• Alliance: Meis1^{tm3.1(cre/ERT2)Mtor} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217599
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Meis1^{tm3.1(cre/ERT2)Mtor} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Meis1 (MGI:104717)

• Mutation details: The last 6 nucleotides from exon 1 and the first 51 nucleotides from intron 1 were replaced with an inducible cre recombinase gene fused with a modified estrogen receptor (ERT2), a loxP site and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:217599)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Meis1 (mouse) Summary of all recombinase alleles driven by Meis1. Comparative matrix view of recombinase activities Alliance mouse Meis1 gene page

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meis1 Mutation: 46 strains or lines available

References

• Original: J:217599 Gonzalez-Lazaro M, et al., Two new targeted alleles for the comprehensive analysis of Meis1 functions in the mouse. Genesis. 2014 Dec;52(12):967-75
• All: 2 reference(s)