Igmsc1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Igmsc1^C57BL/6J
• Name: immunoglobulin M secreting cells 1; C57BL/6J
• MGI ID: MGI:5689584
• QTL: Igmsc1 Location: Chr13:17168545-44918560 bp Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:153393

136 (C57BL/6 x BALB/cJ) F2 mice were informative in mapping QTL Igmsc1 (Immunoglobulin M -secreting cells 1) to mouse Chromosome 13. Serum IgM levels were lower in C57BL/6 then in BALB/cJ. Igmsc1 mapped with a peak LOD score of 3.54 with D13Mit266 and the peak was flanked by D13Mit57 and D13Mit179.

Authors present evidence suggesting Irf4 as a candidate for Igmsc1

References

• Original: J:153393 Corte-Real J, et al., Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse. Genes Immun. 2009 Jan;10(1):93-9
• All: 1 reference(s)