Lacanx2^C58/J
QTL Variant Detail

Summary

• QTL variant: Lacanx2^C58/J
• Name: locomotor activation and anxiety 2; C58/J
• MGI ID: MGI:5689593
• QTL: Lacanx2 Location: unknown Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: C58/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:151136

The authors mapped QTLs associated with locomotor activation and anxiety using 196 female and 166 male F2 mice. The F2 mice were derived from a (C57BL/6J x C58/J)F1 cross and genotyped using a panel of 211 SNP markers, yielding an average SNP density of one marker per 11 mega base pairs. A significant QTL on mouse Chromosome 8 (Lacanx1) is associated with multiple behaviors, including total distance (LOD = 4.1, peak 49 Mb), ambulatory episodes (LOD = 3.8, peak 62 Mb), percent time resting (LOD = 3.5, peak 89 Mb) and average velocity (LOD = 3.3, peak 78 Mb). Two additional QTL that associate with multiple phenotypes were identified. A locus on mouse Chromosome 6 (Lacanx 2)is significant for total distance (LOD = 3.3, peak 47 Mb) and suggestive for both ambulatory episodes (LOD = 2.7, peak 49 Mb) and percent time resting (LOD = 2.8, peak 49 Mb). A QTL on mouse Chromosome 1 (Lacanx 3) (LOD = 3.3, peak 160 Mb) is significantly associated with percent time spent in the center of the open field and suggestive for average velocity (LOD = 2.6, peak 160 Mb).QTL loci that were alsofound to associate with multiple measures, a significant QTL was also identified on mouse Chromosome 13( Lacanx 4) (LOD = 3.6, peak 77 Mb) that associates specifically with percent time spent in the center of the open field.

References

• Original: J:151136 Bailey JS, et al., Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains. Genes Brain Behav. 2008 Oct;7(7):761-9
• All: 1 reference(s)