Kdelr1^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kdelr1^em1Btlr
• Name: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:5689886
• Synonyms: Kdelr1^U2077
• Gene: Kdelr1 Location: Chr7:45522264-45533150 bp, + strand Genetic Position: Chr7, 29.57 cM
• Alliance: Kdelr1^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6JJcl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mutagenesis induced a 4 bp deletion that causes a frame shift mutation and premature termination. (J:224970)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdelr1 Mutation: 10 strains or lines available

References

• Original: J:224970 Siggs OM, et al., Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5706-14
• All: 1 reference(s)