Lmr23^STS/A
QTL Variant Detail

Summary

• QTL variant: Lmr23^STS/A
• Name: leishmaniasis resistance 23; STS/A
• MGI ID: MGI:5689916
• Synonyms: Lmr23^CcS11/Dem
• QTL: Lmr23 Location: Chr16:12674057-12674200 bp Genetic Position: Chr16, Syntenic

Variant origin

• Strain of Specimen: STS/A

Variant description

• Allele Type: QTL
• Mutation: Undefined
• The highest level of IFN gamma was observed in STS/A homozygotes at both Lmr23 ans Lmr20c. (J:152405)

Notes

Candidate Genes

J:152405

Potential candidated gene mapping near the Lmr23 QTL which mapped with D16Mit73 at 6.8 cM on Chromosome 16 of CcS11/Dem in this map study are:

Two clusters of genes that affect B-cell development:

Igl-C5, Igll1, Vpreb1, Vpreb2, Iglc1, Iglc3, Iglv1, Iglv2, and Igll1 mapping between 9.8 and 13.0 cM. [Table 9.]

A possibly related QTL controlling other infections and co-localizing with the Lmr23 QTL is Dice1, determination of interleukin 4 commitment 1 at 8.0 cM. [Table 10.]

References

• Original: J:152405 Kurey I, et al., Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics. 2009 Sep;61(9):619-33
• All: 1 reference(s)