Lmr22^BALB/cHeA
QTL Variant Detail

Summary

• QTL variant: Lmr22^BALB/cHeA
• Name: leishmaniasis resistance 22; BALB/cHeA
• MGI ID: MGI:5689918
• QTL: Lmr22 Location: Chr12:5418440-5418579 bp Genetic Position: Chr12, Syntenic

Variant origin

• Strain of Specimen: BALB/cHeA

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: The highest and lowest levels of IL-4 were observed in BALB/c and STS/A homozygotes, respectively, at both Lmr22 and Lmr32f. (J:152405)

Notes

Candidate Genes

J:152405

A potential candidated gene mapping near the Lmr22 QTL which mapped with D12Mit37 at 1.0 cM on Chromosome 12 of CcS11/Dem in this map study is Adam17, a disintegrin and metallopeptidase domain 17 mapping to 3.0 cM. [Table 9.]

Possibly related QTL controlling other infections and co-localizing with the Lmr22 QTL are:

Cinda2, cytokine induced activation 2 at 1.0 cM; and

Cd4ts5, CD4 T cell subset 5 at 6.0 cM. [Table 10.]

References

• Original: J:152405 Kurey I, et al., Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics. 2009 Sep;61(9):619-33
• All: 1 reference(s)