Gdap1^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Gdap1^tm1.2Geno
• Name: ganglioside-induced differentiation-associated-protein 1; targeted mutation 1.2, Genoway
• MGI ID: MGI:5690110
• Gene: Gdap1 Location: Chr1:17215586-17234495 bp, + strand Genetic Position: Chr1, 5.21 cM, cytoband A4
• Alliance: Gdap1^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224701
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a FRT flanked neomycin positive selection gene and a loxP site were inserted downstream of exon 1 by homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 1. Western blot analysis confirmed absence of protein. (J:224701)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdap1 Mutation: 23 strains or lines available

References

• Original: J:224701 Barneo-Munoz M, et al., Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy. PLoS Genet. 2015 Apr;11(4):e1005115
• All: 4 reference(s)