Bpq20^BTBR
QTL Variant Detail

Summary

• QTL variant: Bpq20^BTBR
• Name: blood pressure QTL 20; BTBR
• MGI ID: MGI:5690155
• QTL: Bpq20 Location: unknown Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: BTBR

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:153906

Systolic blood pressure was measured using the tail cuff method in an attempt to identify QTL effecting blood pressure in mice. F2 mice were generated using 37 inbred strains producing a total of 2577 mice. The following QTL were found below , after the QTL is the chromosome, cross used, cM location, 95% confidence Interval in cM and in Mb, LOD score and high allele

Chr 1 Bpq24 ( C3H/HeJ X KK/HlJ) peak cM = 66.2 cM 95% range in cM =52.6 cM to 80.6cM 95% range in Mb = 106.4 Mb to 161.8Mb LOD= 3.85 Highallele = Unknown

Chr 3 Bpq16 (129S1/SvImJ X DBA/2) peak cM = 21.8 range in cM =3.8 to 40.6 range in Mb = 7.5 to 80.5 LOD=3.96 High allele = DBA/2

Chr 3 Bpq20 (BTBR T⁺ Itpr3^tf/J X SWR/J) peak cM = 27.8 range in cM =19.6 to 43.6 range in Mb = 39.4 to 86.5LOD=12.10 High allele = SWR/J

Chr3 Bpq28 (SJL/J X RIIIS/J) peak cM = 61.8 range in cM =43.6 to 76.1 range in Mb = 86.5 to 151.6 LOD=3.88 High allele = RIIIS/J

Chr 4 Bpq25 ( C3H/HeJ X KK/HlJ ) peak cM 57.6 range in cM =3.6 to 69.1 range in Mb = 7.7 to 139.8 LOD=3.98 High allele = C3H/HeJ

Chr 4 Bpq27 (FVB/NJ X RIIIS/J) peak cM 65.2 range in cM =44.5 to 69.1 range in Mb = 90.9 to 139.8 LOD=3.59 High allele = RIIIS/J

Chr 5 Bpq14 (129S1/SvImJ X A) peak cM 42.5 range in cM =22.5 to 67.4 range in Mb = 46.4to 136.5 LOD=3.77 High allele = A

Chr 5 Bpq29 (SJL/J X RIIIS) peak cM 54.2 range in cM =40.1 to 73.5 range in Mb = 88.7 to 148.3 LOD=5.46 High allele = RIIIS/J

Chr8 Bpq26( C3H/HeJ X KK/HlJ) peak cM 42.6 range in cM =31.0 to 62.5 range in Mb = 65.7 to128.0 LOD=6.22 High allele = KK/HlJ

Chr 9 Bpq30 (SJL/J X RIIIS) peak cM 6.7 range in cM =6.7 to 18.9 range in Mb = 13.2 to 37.4 LOD=4.13 High allele = RIIIS/J

Chr 11 Bpq19 (AKR/J X NZW/LacJ) peak cM 46.1 range in cM =6.1 to 51.5 range in Mb = 12.2 to102.0LOD=3.82 High allele = AKR/J

Chr12 Bpq17 (129S1/SvImJ X DBA/2) peak cM = 30.1 range in cM =8.1 to 52.1 range in Mb = 16.2 to 110.4 LOD=5.69 High allele = 129S1/SvlmJ

Chr13 Bpq15 (129S1/SvImJ X A/J) peak cM= 44.9 range in cM =23.9 to 51.0 range in Mb = 48.2 to 105.6 LOD=5.39 High allele = 129S1/SvlmJ

Chr 15 Bpq18 (129S1/SvlmJ X DBA/2) peak cM 28.6 range in cM =4.6 to 48.7 range in Mb = 9.0 to 96.4 LOD=4.53 High allele = 129S1/SvlmJ

References

• Original: J:153906 Feng M, et al., Genetic analysis of blood pressure in 8 mouse intercross populations. Hypertension. 2009 Oct;54(4):802-9
• All: 1 reference(s)