Ccs3^A/J
QTL Variant Detail

Summary

• QTL variant: Ccs3^A/J
• Name: colon cancer susceptibility 3; A/J
• MGI ID: MGI:5690196
• QTL: Ccs3 Location: Chr3:131754536-146017669 bp Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:157016

Inbred mouse strains differ in carcinogen induced colorectal cancer. The authors identified a gene responsible for the genetic control of colorectal cancer in resistant C57BL/6J mice and susceptible A/J mice. 35 reciprocal AcB/BcA recombinant strains (RCS) were informative in mapping the resistant/ susceptible locus In the AcB/BcA RCS 625 markers were analyzed. The authors provide data showing a colorectal cancer locus Ccc3 mapping with loci in mouse Chromosome 3. Ccs3 mapped between D3Mit254 (132.0 Mb) and D3Mit292. Within the interval there are a number of positional candidates including Bcl10, Rap1gds, Gbp2 and Gbp3.

References

• Original: J:157016 Meunier C, et al., Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3. Oncogene. 2010 Feb 4;29(5):647-61
• All: 1 reference(s)