Snx10^{tm1c(EUCOMM)Raba}
Targeted Allele Detail

Summary

• Symbol: Snx10^{tm1c(EUCOMM)Raba}
• Name: sorting nexin 10; targeted mutation 1c, Ricardo A Battaglino
• MGI ID: MGI:5690197
• Synonyms: Snx10^f
• Gene: Snx10 Location: Chr6:51500882-51567659 bp, + strand Genetic Position: Chr6, 24.95 cM, cytoband B3
• Alliance: Snx10^{tm1c(EUCOMM)Raba} page

3-week-old Ctsk^tm1(cre)Ska/Ctsk^tm1(cre)Ska Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba} mice are growth retarded, have a tooth eruption defect, and are osteopetrotic

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224711
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette (vector PG00216_Z_2_C06) was inserted at position 51556250 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 51557821. The critical exons 4 and 5 are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. (J:224711)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snx10 Mutation: 142 strains or lines available

References

• Original: J:224711 Ye L, et al., Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption. PLoS Genet. 2015 Mar;11(3):e1005057
• All: 3 reference(s)