Cdcs12^{B6.129P2-Il10-tm1Cgn/J}
QTL Variant Detail

Summary

• QTL variant: Cdcs12^{B6.129P2-Il10-tm1Cgn/J}
• Name: cytokine deficiency colitis susceptibility 12; B6.129P2-Il10^tm1Cgn/J
• MGI ID: MGI:5690209
• QTL: Cdcs12 Location: unknown Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: B6.129P2-Il10^tm1Cgn/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94027

Two different methods were used to assess lesion phenotypes of the colon and cecum and their power to detect colitis QTLs. 259 (C3Bir.129P2-Il10^tm1Cgn/J x B6.129P2-Il10^tm1Cgn/J)F1 x C3Bir.129P2-Il10^tm1Cgn/J backcross animals were used for linkage analysis. A total of 359 mice were analyzed, which includes parental and F1 hybrid animals. All animals were assessed using both scoring methods. Parental strain C3H/HeJBir is susceptible to colitis while parental strain C57BL/6J is resistant.

The more detailed scoring method by The Jackson Lab (TJL) was more powerful in detecting a colitis susceptibility locus, Cdcs11, on mouse Chromosome 3 compared to the less detailed Hanover Medical School (MHH) method. In this study, TJL method detected linkage to distal colon phenotypes at D3Mit257 (70.3 cM, LOD=2.61) and total colon phenotypes at D3Mit199 (60.5 cM, LOD=2.64). Linkage to total parameters (which included severity, hyperplasia, ulceration, and area involved) yielded higher LOD scores at D3Mit199 (LOD=4.08) and D3Mit257 (LOD=4.28) using TJL method.

Using the more simple MHH method, only linkage to distal colon phenotypes, represented by QTL Cdcs12, could be detected at D3Mit18 (76 cM) with a lower LOD score (LOD=1.77).

References

• Original: J:94027 Bleich A, et al., Refined histopathologic scoring system improves power to detect colitis QTL in mice. Mamm Genome. 2004 Nov;15(11):865-71
• All: 1 reference(s)