Cypr6^O20/A
QTL Variant Detail

Summary

• QTL variant: Cypr6^O20/A
• Name: cytokine production 6; O20/A
• MGI ID: MGI:5691710
• QTL: Cypr6 Location: Chr4:137617848-137617995 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: O20/A

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:152894

F2 mice derived from (O20/A X OcB9/Dem)F1 were used in the QTL mapping experiments. The proliferation of lymphocytes of strain OcB-9/Dem in mixed lymphocyte cultures is higher than O20/A indicating OcB9/Dem has a higher potential to respond to alloantigens then does O20/A. The authors indentified four QTL loci that influence the aforementioned difference in proliferation. Two loci have individual effects, Cypr4 (38.5 cM) which is linked to D6Mit31 (p <.007177)and Cypr5 (61.4 cM) which is linked to D6Mit52 (p <.000257). The other two loci Cypr6(66.0 cM) and Cypr7(10.0 cM) which map to D4Mit54 and D8Mit3 respectively interact with each other.

References

• Original: J:152894 Lipoldova M, et al., Loci controlling lymphocyte production of interferon c after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility. Cancer Immunol Immunother. 2010 Feb;59(2):203-13
• All: 1 reference(s)