Ldoc1^tm1.1Tmki
Targeted Allele Detail

Summary

• Symbol: Ldoc1^tm1.1Tmki
• Name: regulator of NFKB signaling; targeted mutation 1, Tomoko Kaneko-Ishino
• MGI ID: MGI:5691781
• Synonyms: Sirh7/Ldoc1^-
• Gene: Ldoc1 Location: ChrX:60753217-60754556 bp, + strand Genetic Position: ChrX, 34.57 cM
• Alliance: Ldoc1^tm1.1Tmki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217586
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the entire coding sequence of the gene. The neomycin cassette was removed via cre-mediated recombination in ES cells prior to the generation of mutant mcie. (J:217586)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldoc1 Mutation: 4 strains or lines available

References

• Original: J:217586 Naruse M, et al., Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition. Development. 2014 Dec;141(24):4763-71
• All: 1 reference(s)