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Ldoc1tm1.1Tmki
Targeted Allele Detail
Summary
Symbol: Ldoc1tm1.1Tmki
Name: regulator of NFKB signaling; targeted mutation 1, Tomoko Kaneko-Ishino
MGI ID: MGI:5691781
Synonyms: Sirh7/Ldoc1-
Gene: Ldoc1  Location: ChrX:60753217-60754556 bp, + strand  Genetic Position: ChrX, 34.57 cM
Alliance: Ldoc1tm1.1Tmki page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:217586
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced the entire coding sequence of the gene. The neomycin cassette was removed via cre-mediated recombination in ES cells prior to the generation of mutant mcie. (J:217586)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ldoc1 Mutation:  4 strains or lines available
References
Original:  J:217586 Naruse M, et al., Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition. Development. 2014 Dec;141(24):4763-71
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory