Ril6^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Ril6^C57BL/6J
• Name: radiation-induced leukemia sensitivity 5; C57BL/6J
• MGI ID: MGI:5691817
• QTL: Ril6 Location: unknown Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:9343

Measurement of Ril1 mediated radiation-induced leukemia susceptibility in congenic strains demonstrated that Ril1 is on Chromosome 15. Evidence from congenic strain pairs included high susceptibility in B6.C-H30^c and lower susceptibility in C57BL/6JBy,suggesting linkage of Ril1 and H30 and high susceptibility in C3H.B6-Ly-6^b and lower susceptibility in C3H/HeJ suggesting linkage of Ril1 and Ly6.

10.19.2015 Curator Note: Because Ril1 was originally mapped in J:6610,in 1981 to Chr 2 using an (A/J x C57BL/10ScSn)F2 intercross, we consider the congenics used here to be mapping unique QTL. We have labeled the QTL identified using the B6.C-H30^c congenics as Ril5; and the QTL identified using the C3H.B6-Ly-6^b congenics as Ril6.

References

• Original: J:9343 Amari NM, et al., Reverse genetics approaches for cloning RIL-1, a major locus involved in susceptibility to leukemia. Curr Top Microbiol Immunol. 1988;137:256-63
• All: 1 reference(s)