Grid2^ho-2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Grid2^ho-2Btlr
• Name: glutamate receptor, ionotropic, delta 2; hotfoot 2 Bruce Beutler
• MGI ID: MGI:5691954
• Synonyms: crawler
• Gene: Grid2 Location: Chr6:63232860-64681307 bp, + strand Genetic Position: Chr6, 29.77 cM
• Alliance: Grid2^ho-2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: T to A transversion at base pair 64,429,694 (v38) on chromosome 6, or base pair 1,173,792 in the GenBank genomic region NC_000072 encoding Grid2. The mutation corresponds to residue 2,037 (c.2037T>A) in the NM_008167.3 mRNA sequence in exon 13 of 16 total exons. The mutation results in substitution of tyrosine 679 for a premature stop codon (p.Y679*) in the GluRdelta2 protein. (J:225267)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grid2 Mutation: 85 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=1607

References

• Original: J:225267 SoRelle J, et al., Mutagenetix entry for crawler. MGI Direct Data Submission. 2015
• All: 1 reference(s)