Nos3^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nos3^m1Btlr
• Name: nitric oxide synthase 3, endothelial cell; mutation 1, Bruce Beutler
• MGI ID: MGI:5691955
• Synonyms: paul
• Gene: Nos3 Location: Chr5:24569808-24589472 bp, + strand Genetic Position: Chr5, 11.32 cM
• Alliance: Nos3^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to T transition at base pair 24,372,704 (v38) on chromosome 5, or base pair 7,886 in the GenBank genomic region NC_000071, corresponding to residue 1,734 in the mRNA sequence NM_008713 within exon 13 of 26 total exons. The mutation results in a threonine (T) to isoleucine (I) substitution at position 572 (T572I). (J:225268)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nos3 Mutation: 58 strains or lines available

References

• Original: J:225268 Turer E, et al., Mutagenetix entry for paul. MGI Direct Data Submission. 2015
• All: 1 reference(s)