Ikbkb^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ikbkb^M1Btlr
• Name: inhibitor of kappaB kinase beta; mutation 1, Bruce Beutler
• MGI ID: MGI:5691958
• Synonyms: Impaired
• Gene: Ikbkb Location: Chr8:23149228-23196605 bp, - strand Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
• Alliance: Ikbkb^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a a T to C transition at base pair 22,666,020 (v38) on chromosome 8, or base pair 40,566 in the GenBank genomic region NC_000074, corresponding to residue 1,841 in the mRNA sequence NM_001159774 (variant 1) within exon 17 of 22 total exons and to residue 1,841 in the mRNA sequence NM_010546 (variant 2) within exon 17 of 21 total exons. The mutation results in an leucine (L) to proline (P) substitution at position 570 (L570P) in both isoforms of the protein. (J:225271)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikbkb Mutation: 56 strains or lines available

References

• Original: J:225271 SoRelle J, et al., Mutagenetix entry for Impaired. MGI Direct Data Submission. 2015
• All: 1 reference(s)