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Fss3C57BL/6J
QTL Variant Detail
Summary
QTL variant: Fss3C57BL/6J
Name: febrile seizure susceptibility 3; C57BL/6J
MGI ID: MGI:5692027
QTL: Fss3  Location: unknown  Genetic Position: Chr6, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:151141

Febrile seizures susceptibility (FS) and

febrile seizure latency (FSL) were determined in both sexes of the host strain

(C57BL/6J), the donor strain (A/J) and mouse chromosome substitution

strains (CSS) to identify novel FS susceptibility quantitative

trait loci. C57BL/6J mice were more susceptible to FS than A/J mice.

Strains CSS 1, CSS 2, CSS 6, CSS 10, CSS 13 and CSS X representing Chrs 1, 2, 6, 10 ,13 and X respectively were identified as significantly different from strain (C57BL/6J; P <

0.003) and thus are presumed by the authors to contain 1 or more loci that affect FS in mice. These QTLs are symbolized as Fss1(chr1), Fss2(chr2), Fss3(chr6), Fss4(chr10) and Fss5(Chr 13) and Fss6(Chr X).

References
Original:  J:151141 Hessel EV, et al., Phenotyping mouse chromosome substitution strains reveal multiple QTLs for febrile seizure susceptibility. Genes Brain Behav. 2009 Mar;8(2):248-55
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory