Fss4^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Fss4^C57BL/6J
• Name: febrile seizure susceptibility 4; C57BL/6J
• MGI ID: MGI:5692032
• QTL: Fss4 Location: unknown Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:151141

Febrile seizures susceptibility (FS) and

febrile seizure latency (FSL) were determined in both sexes of the host strain

(C57BL/6J), the donor strain (A/J) and mouse chromosome substitution

strains (CSS) to identify novel FS susceptibility quantitative

trait loci. C57BL/6J mice were more susceptible to FS than A/J mice.

Strains CSS 1, CSS 2, CSS 6, CSS 10, CSS 13 and CSS X representing Chrs 1, 2, 6, 10 ,13 and X respectively were identified as significantly different from strain (C57BL/6J; P <

0.003) and thus are presumed by the authors to contain 1 or more loci that affect FS in mice. These QTLs are symbolized as Fss1(chr1), Fss2(chr2), Fss3(chr6), Fss4(chr10) and Fss5(Chr 13) and Fss6(Chr X).

References

• Original: J:151141 Hessel EV, et al., Phenotyping mouse chromosome substitution strains reveal multiple QTLs for febrile seizure susceptibility. Genes Brain Behav. 2009 Mar;8(2):248-55
• All: 1 reference(s)