Sycp2l^tm1Jw
Targeted Allele Detail

Summary

• Symbol: Sycp2l^tm1Jw
• Name: synaptonemal complex protein 2-like; targeted mutation 1, Jeremy Wang
• MGI ID: MGI:5692068
• Gene: Sycp2l Location: Chr13:41267895-41327827 bp, + strand Genetic Position: Chr13, 20.32 cM
• Alliance: Sycp2l^tm1Jw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225272
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector was designed to replace exons 8-14 of the synaptonemal complex protein 2-like gene (Sycp2l) on chromosome 13 with a loxP-flanked PGK-neo cassette. The absence of protein expression was confirmed by Western blot analysis and immunostaining on ovarian extracts. (J:225272)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sycp2l Mutation: 30 strains or lines available

References

• Original: J:225272 Zhou J, et al., Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L. Hum Mol Genet. 2015 Nov;24(22):6505-14
• All: 1 reference(s)