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Gre1C57BL/6
QTL Variant Detail
Summary
QTL variant: Gre1C57BL/6
Name: Glucocorticoid receptor expression 1; C57BL/6
MGI ID: MGI:5692075
QTL: Gre1  Location: Chr18:43541078-46536999 bp  Genetic Position: Chr18, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:166381

SPRET/Ei mice are resistant to acute LPS-induced lethal inflammation wherein C57BL/6.are resistant. The role of the anti inflammatory phenotype provided by glucocorticoid receptors was investigated. The strains differences between inflammations allow for the mapping of glucocorticoid mRNA levels to mouse Chromosome 18 between D18Mit163 and D18Mit58 to cM position 20 with an LRS of 21.9 with D18Mit163 and 47.7 with D18Mit58. The linkage relationships the various microsatellites are detailed in Table 1 ofthe reference. Authors suggest Nr3c1 as the locus responsible for high glucocorticoid mRNA levels in SPRET/Ei mice.

References
Original:  J:166381 Dejager L, et al., Increased glucocorticoid receptor expression and activity mediate the LPS resistance of SPRET/EI mice. J Biol Chem. 2010 Oct 1;285(40):31073-86
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory