Tjp1^tm1Sats
Targeted Allele Detail

Summary

• Symbol: Tjp1^tm1Sats
• Name: tight junction protein 1; targeted mutation 1, Sachiko Tsukita
• MGI ID: MGI:5692184
• Synonyms: Tjp1^-, ZO-1 deficient, ZO-1 knockout
• Gene: Tjp1 Location: Chr7:64945913-65177529 bp, - strand Genetic Position: Chr7, 35.02 cM
• Alliance: Tjp1^tm1Sats page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222380
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A beta-geo selection cassette replaced part of exon 2 and all of exon 3. Western blot analysis of embryonic extracts confirmed the absence of protein expression in homozygous mutant embryos. (J:222380)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tjp1 Mutation: 66 strains or lines available

References

• Original: J:222380 Katsuno T, et al., Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell. 2008 Jun;19(6):2465-75
• All: 1 reference(s)