Rock2^tm1Zpj
Targeted Allele Detail

Summary

• Symbol: Rock2^tm1Zpj
• Name: Rho-associated coiled-coil containing protein kinase 2; targeted mutation 1, Zhengping Jia
• MGI ID: MGI:5692187
• Gene: Rock2 Location: Chr12:16944896-17037824 bp, + strand Genetic Position: Chr12, 8.04 cM, cytoband A3
• Alliance: Rock2^tm1Zpj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225274
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 5. Western blot analysis confirmed the absence of protein expression in the brain. (J:225274)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rock2 Mutation: 60 strains or lines available

References

• Original: J:225274 Zhou Z, et al., A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function. Neuropharmacology. 2009 Jan;56(1):81-9
• All: 2 reference(s)