Mnp^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Mnp^DBA/2J
• Name: modifier of Niemann Pick type C1; DBA/2J
• MGI ID: MGI:5692194
• QTL: Mnp Location: Chr19:37234314-37234461 bp Genetic Position: Chr19, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:59225

88 F2 mice derived from a cross between BALB/cJ and DBA/2J mice were analyzed for the severity of Niemann-Pick C1 disease. Two broad categories of the disease were identified based on the onset of symptoms. One group was classified as severely affected while the other mildly affected. Thus grouping allowed for the statistical analysis of F2 mice using an end mapping strategy that identified nonrecombinant DBA/2J and BALB/cJ chromosomes. For mouse Chromosome 19 the number of nonrecombinant BALB/cJ chromosomes was greater in the severely affected group, wheras the number of DBA/2J nonrecombinant chromosomes was greater in the midly affected group. These findings suggest that a modifier of Chromosome 18 locus Npc1 may reside on mouse Chromosome 19. Moreovera QTL, analysis led to the observation that this modifier locus called Mnp was associated with marker D19Mit88 (LOD of approximately 2.0).

References

• Original: J:59225 Zhang J, et al., A modifier of Niemann Pick C 1 maps to mouse chromosome 19. Mamm Genome. 2000 Jan;11(1):69-71
• All: 1 reference(s)