Nirep^CBA/J
QTL Variant Detail

Summary

• QTL variant: Nirep^CBA/J
• Name: noise induced reduction in endocochlear potential; CBA/J
• MGI ID: MGI:5692222
• QTL: Nirep Location: unknown Genetic Position: Chr18, Syntenic

Variant origin

• Strain of Specimen: CBA/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:155891

Neither C57BL/6J nor C57BL/6J.Cast congenic mice undergo endocochlear potential (EP) reduction when exposed to noise whereas CBA/J and CBA/CaJ do. This difference allowed for the mapping of EP in 80 (C57BL/6J X CBA/J) X C57BL/6J backcross mice and in 26 C57BL/6J.CAST congenics. QTL Nirep mapped with Chromosome 18 locus c18.loc8 at 12.5 cM with a LOD 0f 3.57. Suggestive QTL were found in chromosome 5 and chromosome 16.

References

• Original: J:155891 Ohlemiller KK, et al., A major effect QTL on chromosome 18 for noise injury to the mouse cochlear lateral wall. Hear Res. 2010 Feb;260(1-2):47-53
• All: 1 reference(s)