Org4^SM/J
QTL Variant Detail

Summary

• QTL variant: Org4^SM/J
• Name: organ weight 4; SM/J
• MGI ID: MGI:5692230
• QTL: Org4 Location: unknown Genetic Position: Chr6, cM position of peak correlated region/allele: 6.68 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:109795

Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.

On mouse Chromosome 6, linkage to heart and kidney weight mapped to approximately 36 cM near D6Mit1 (LPR=11). This locus is also associated with necropsy body weight and is named Org4 (organ weight 4). The confidence interval spans 22 cM - 48 cM. Previously identified QTL Skl3 (36.5 cM) may be identical to Org4.

Linkage to ulna length, Lbn5 (long bones 5), mapped to 44 cM near D6Mit9 (LPR=7.28). The Lbn5 confidence interval spans 42 cM - 68 cM. Potential candidate genes mapping near Lbn5 include Wnt7a (39.5 cM), Fbln2 (37.2 cM), Foxp1, Itpr1 (48 cM), and Tpt1 (*note: this gene maps to chromosome 14 according to data in MGD).

Bod3 (bone length and organs 3) mapped to 81 cM near D6Mit58(LPR=5.17). This locus is associated with necropsy body weight, liver and spleen weights, and femur, humerus, and tibia lengths. Bod3 ssociation with spleen weight is female-specific. The confidence interval spans 30 cM - 98 cM. Previously identified QTLs Wta2 (67 cM) and Adip2 (46.3 cM) may be identical toBod3. Potential candidate genes mapping near Bod3 include Pthlh (74 cM), Sox5 (69.5 cM), Fgfr1op2, Cmas (74 cM), Bcat1 (73.9 cM), Kras (71.2 cM), Wnt7a, Fbln2, Foxp1, Itpr1, and Tpt1.

References

• Original: J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• All: 1 reference(s)