Org6^LG/J
QTL Variant Detail

Summary

• QTL variant: Org6^LG/J
• Name: organ weight 6; LG/J
• MGI ID: MGI:5692233
• QTL: Org6 Location: unknown Genetic Position: Chr10, cM position of peak correlated region/allele: 46.85 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: LG/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:109795

Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.

On mouse Chromosome 10, linkage to humerus length mapped to 56 cM near D10Mit65 (LPR=5.11). This locus is named Lbn9 (long bones 9). The confidence interval spans 54 cM - 82 cM. Potentialcandidate genes mapping near Lbn9 include Rfx4, Igf1 (48 cM), Fbxo7, Cry1 (46 cM), Arl1, and Snrpf.

Linkage to liver weight, Org6 (organ weight 6), mapped to 57 cM near D10Mit10 (LPR=5.15). This locus is also associated with necropsy body weight and maybe identical to previously identified QTL Skl4 at 59 cM. The confidence interval spans 68 cM - 86 cM.

Linkage to spleen weight and ulna length mapped to 67 cM near D10Mit133 (LRS=2.63). (The effect on ulna length is female-specific.) This locus is namedBod6 (bone length and organs 6). The confidence interval spans 70 cM - 88 cM. Tbk1 and Xpot are potential candidate genes for Bod6.

References

• Original: J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• All: 1 reference(s)