Org7^SM/J
QTL Variant Detail

Summary

• QTL variant: Org7^SM/J
• Name: organ weight 7; SM/J
• MGI ID: MGI:5692236
• QTL: Org7 Location: unknown Genetic Position: Chr11, cM position of peak correlated region/allele: 33.39 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:109795

Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.

On mouse Chromosome 11, linkage to spleen weight in females mapped to 38 cM near D11Mit64 (LPR=3.14). This locus is named Org7 (organ weight 7). The Org7 confidence interval spans 46 cM -70 cM.

Bwtn3 (body weight at necropsy 3) mapped to 62 cM near D11Mit15 (LPR=2.4). This locus is male-specific. The Bwtn3 confidence interval spans 66 cM - 90 cM. Previously identified QTL Skl5 (40 cM) may be identical to Bwtn3.

References

• Original: J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• All: 1 reference(s)