Ppsl^{B6.129P2-Apoe-tm1Unc/J}
QTL Variant Detail

Summary

• QTL variant: Ppsl^{B6.129P2-Apoe-tm1Unc/J}
• Name: plasma P-selectin levels; B6.129P2-Apoe^tm1Unc/J
• MGI ID: MGI:5692259
• QTL: Ppsl Location: Chr16:13814404-13814572 bp Genetic Position: Chr16, Syntenic

Variant origin

• Strain of Specimen: B6.129P2-Apoe^tm1Unc/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:153398

C57BL/6J mice display higher VCAM-1 levels then resistant strain C3H/HeJ and BALB/c. Soluble P-selectin levels are also higher in B6.apoE-/- then in BALB/c apoE-/- A total of 234 female animals from a (B6.129P2-Apoe^tm1Unc/J x C3.129P2(B6)-Apoe^tm1Unc)F2 intercross facilitated the QTL mapping of these levels in a genome wide scan . The cross is detailed in J:106521 Su Z, Genetics 2006 Mar;172(3):1799-807. Pvacm1l mapped to mouse Chromosome 9 with a peak LOD of 3.9 at D9Mit18. Genetic control of plasma VCAM-1 levels also showed suggestive loci on chromosomes 5, 13 and 15. Ppsl showed a peak at D16Mit165 with a LOD of 3.4. For soluble P-selectin levels suggestive loci were indicated in mouse Chromosomes 10 and 13. A peak cM of 71 cM and 8.5 cM was suggested for Pvacm1l and Ppsl respectively.

References

• Original: J:153398 Yuan Z, et al., Quantitative trait locus analysis of circulating adhesion molecules in hyperlipidemic apolipoprotein E-deficient mice. Mol Genet Genomics. 2008 Nov;280(5):375-83
• All: 1 reference(s)