Tlx1^{tm1.1(cre/ERT2)Rygo}
Targeted Allele Detail

Summary

• Symbol: Tlx1^{tm1.1(cre/ERT2)Rygo}
• Name: T cell leukemia, homeobox 1; targeted mutation 1.1, Ryo Goitsuka
• MGI ID: MGI:5692287
• Synonyms: Tlx1^CreER-Venus
• Gene: Tlx1 Location: Chr19:45139119-45145382 bp, + strand Genetic Position: Chr19, 38.45 cM
• Alliance: Tlx1^{tm1.1(cre/ERT2)Rygo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217489
• Parent Cell Line: EGR-101 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Tlx1^{tm1.1(cre/ERT2)Rygo} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tlx1 (MGI:98769)

• Mutation details: The targeting construct inserted into the translation start site in exon 1 an inducible cre recombinase gene (cre/ERT2), an IRES sequence, a Venus reporter gene and a FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:217489)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tlx1 (mouse) Summary of all recombinase alleles driven by Tlx1. Comparative matrix view of recombinase activities Alliance mouse Tlx1 gene page

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlx1 Mutation: 20 strains or lines available

References

• Original: J:217489 Nakahara R, et al., Generation of a Tlx1(CreER-Venus) knock-in mouse strain for the study of spleen development. Genesis. 2014 Nov;52(11):916-23
• All: 2 reference(s)