Ssen1^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Ssen1^DBA/2J
• Name: suseptibility to Sendai virus 1; DBA/2J
• MGI ID: MGI:5692299
• QTL: Ssen1 Location: Chr4:109658132-133154782 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:153513

C57BL/6J (B6) and DBA/2J (D2) differ in susceptibility to Sendai virus infection. B6 is resistant whereas D2 is susceptible to Sendai virus. Various crosses using B6 and D2 were utilized in a genome wide scan with STS markers to indentify QTL responsible for the resistant/susceptible phenotype. A significant locus , Ssen1, in mouse Chromosome 4 at 23 cM was found between D4Mit146 and D4Mit204 with a LRS of 14.5. Suggestive linkage was found in chromosome 8 , between D8Mit4 and D8Mit100 and again in chromosome 14 between the centromere and D14Mit10. The authors investigated epistatic interaction using (B6 X D2) backcross mice. A significant epistatic interactions were found between D3Mit182 and D14Mit10 with a p value less the 0.0001. The chromosome3 locus was designated as Ssen2 and as Ssen3 for the chromosome 14 locus. A list of candidate genes for Ssen1, Ssen2 and Ssen3 are listed in table 2 of the mapping reference.

References

• Original: J:153513 Simon AY, et al., Multigenic control of resistance to Sendai virus infection in mice. Infect Genet Evol. 2009 Dec;9(6):1253-9
• All: 1 reference(s)