Wra1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Wra1^C57BL/6J
• Name: wheel running activity 1; C57BL/6J
• MGI ID: MGI:5692446
• QTL: Wra1 Location: Chr13:76132600-76132738 bp Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:153440

Consomic CCS13 is a strain that has a chromosome 13 derived from A/J on a C57BL/6J background. Thirteen male mice from CCS13 had higher wheel running and total cage activity then C57BL/6J suggesting an involvement of an A/J chromosome 13. A total of 189(C57BL/6J x CCS-13) F2 mice were analyzed in a chromosome 13 scan to discover any QTL that contributed to the increased activity levels. A significant QTL ( Wra1 ) associated with wheel running activity was observed between 21 and 95 Mbp. A peak LODfor Wra of 7.3 was found at 76 Mbs in association with D13Mit254. Wra1 accounts for 10% of the total variance in the F2 population.

References

• Original: J:153440 Yang HS, et al., Genetic analysis of daily physical activity using a mouse chromosome substitution strain. Physiol Genomics. 2009 Sep 9;39(1):47-55
• All: 1 reference(s)