Tg(Krt19-cre/ERT2)#Tcw
Transgene Detail

Summary

• Symbol: Tg(Krt19-cre/ERT2)#Tcw
• Name: transgene insertion, Timothy C Wang
• MGI ID: MGI:5692448
• Synonyms: Krt19-CreERT2
• Transgene: Tg(Krt19-cre/ERT2)#Tcw Location: unknown
• Alliance: Tg(Krt19-cre/ERT2)#Tcw page

Transgene origin

• Strain of Origin: CBA x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Krt19-cre/ERT2)#Tcw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt19 (MGI:96693)

• Mutation details: BAC RP-23-24N13 was used to generate containing an inducible cre recombinase gene (cre/ERT2) inserted at the translation initiation site to achieve expression in the colon and intestine. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:224765)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt19 (mouse) Summary of all recombinase alleles driven by Krt19. Comparative matrix view of recombinase activities Alliance mouse Krt19 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:224765 Asfaha S, et al., Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine. Cell Stem Cell. 2015 Jun 4;16(6):627-38
• All: 1 reference(s)