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Ric8btm1c(EUCOMM)Hmgu
Targeted Allele Detail
Summary
Symbol: Ric8btm1c(EUCOMM)Hmgu
Name: RIC8 guanine nucleotide exchange factor B; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:5692848
Synonyms: Ric-8bflox
Gene: Ric8b  Location: Chr10:84753480-84854201 bp, + strand  Genetic Position: Chr10, 41.63 cM
Alliance: Ric8btm1c(EUCOMM)Hmgu page
IMPC: Ric8b gene page
Mutation
origin
Mutant Cell Line:  HEPD0556_4_C07
Germline Transmission:  Earliest citation of germline transmission: J:204739
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsFlp-mediated excision of the parental Ric8btm1a(EUCOMM)Hmgu allele resulted in the removal of the promoter-driven neomycin selection cassette and the inserted lacZ reporter sequence, leaving behind the loxP-flanked exon 4. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ric8b Mutation:  50 strains or lines available
References
Original:  J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory