Nhdlq13^{B6.129P2-Apoe-tm1Unc/J}
QTL Variant Detail

Summary

• QTL variant: Nhdlq13^{B6.129P2-Apoe-tm1Unc/J}
• Name: non-HDL QTL 13; B6.129P2-Apoe^tm1Unc/J
• MGI ID: MGI:5693293
• QTL: Nhdlq13 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: B6.129P2-Apoe^tm1Unc/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:197549

Linkage analysis was performed on 266 female (B6.129P2-Apoe^tm1Unc/J x C.129P2(B6)-Apoe^tm1Unc)F2 intercross mice using 130 SNP markers to identify QTL associated with non-HDL cholesterol level on a Western diet.

QTL Nhdlq13 maps to 54.31 - 82.31 cM on Chromosome 1 with a peak LOD score of 5.93 at 60.31 cM in linkage with non-HDL cholesterol level. C.129P2(B6)-Apoe^tm1Unc alleles confer increased susceptibility to higher non-HDL cholesterol levels with a dominant mode of inheritance.

References

• Original: J:197549 Rowlan JS, et al., New quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains. Physiol Genomics. 2013 Apr 16;45(8):332-42
• All: 1 reference(s)